About Cleft
Cleft Research
Operation Smile conducts impactful research to enhance both surgical and nonsurgical care for patients and families.
Ensuring a Lasting Impact
Our focus is on improving quality of life through evidence-based programs and influencing global health systems and policies.
Our research spans various areas, from cleft-specific care to broader surgical topics like epidemiology, genetics, outcomes, leadership, and education. We aim to understand the causes of cleft lip and palate to develop preventive measures for future generations, ensuring a lasting impact on cleft care.
Explore Research Collaborated with or Conducted by our Global Operation Smile Team
Genome Analysis Using Whole-Exome Sequencing of Non-Syndromic Cleft Lip and/or Palate from Malagasy Trios Identifies Variants Associated with Cilium-Related Pathways and Asian Genetic Ancestry
Authors: Manojlovic Z, Auslander A, Jin Y, Schmidt RJ, Xu Y, Chang S, Song R, Ingles SA, Nunes A, Vavra KC, Feigelson D, Rakotoarison S, DiBona M, Magee K, Smile O, Ramamonjisoa A, Magee Iii W.
The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries
Authors: Auslander, A., McKean-Cowdin, R., Brindopke, F., Sylvester, B., DiBona, M., Magee, K., Kapoor, R., Conti, D. V., Rakotoarison, S., Magee, W., 3rd, & Operation Smile International Family Study Group*
A Synonymous Exonic Splice Silencer Variant in IRF6 as a Novel and Cryptic Cause of Non-Syndromic Cleft Lip and Palate
Authors: Sylvester, B., Brindopke, F., Suzuki, A., Giron, M., Auslander, A., Maas, R. L., Tsai, B., Gao, H., Magee, W., 3rd, Cox, T. C., & Sanchez-Lara, P. A.
Environmental risk factors for cleft lip and palate in low-resource settings: a case-control study
Authors: Auslander, A., Mckean-Cowdin, R., Brindopke, F., Magee, K., DiBona, M., & Magee, W.
Genomic analyses in African populations identify novel risk loci for cleft palate
Authors: Butali, A., Mossey, P. A., Adeyemo, W. L., Eshete, M. A., Gowans, L., Busch, T. D., Jain, D., Yu, W., Huan, L., Laurie, C. A., Laurie, C. C., Nelson, S., Li, M., Sanchez-Lara, P. A., Magee, W. P., Magee, K. S., Auslander, A., Brindopke, F., Kay, D. M., Caggana, M., Adeyemo, A. A.